Methanesulfonamide → HCID 67540768, compound

HRID 1026900Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:33]=[CH:34][CH:35]=1)[CH2:5][NH:6][C:7]1[N:12]2[N:13]=[CH:14][C:15]([C:16](O)=[O:17])=[C:11]2[N:10]=[CH:9][C:8]=1[C:19]([N:21]1[CH2:26][CH2:25][CH:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:23][CH2:22]1)=[O:20].[CH3:36][S:37]([NH2:40])(=[O:39])=[O:38]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:33]=[CH:34][CH:35]=1)[CH2:5][NH:6][C:7]1[N:12]2[N:13]=[CH:14][C:15]([C:16]([NH:40][S:37]([CH3:36])(=[O:39])=[O:38])=[O:17])=[C:11]2[N:10]=[CH:9][C:8]=1[C:19]([N:21]1[CH2:26][CH2:25][CH:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:23][CH2:22]1)=[O:20]

Participants

Reactant 2

HCID 72879Methanesulfonamide

HCID 67541003HCID 67541003, compound

Product 1

HCID 67540768HCID 67540768, compoundYield 22%

Procedure

In the same manner as in Example 1, step 6 and using 7-(3-chlorobenzylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.08 g, 0.16 mmol) obtained in step 2 and methanesulfonamide (0.08 g, 0.82 mmol), the title compound (0.02 g, 22%) was obtained.

Sources & evidence

ORD record: ord-c296a9e0dc0f4b91b629161cb0aa60d1
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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