Methanesulfonamide → HCID 67540773, compound

HRID 1026903Notes

Reaction equation

[CH:1]1([NH:10][C:11]2[N:16]3[N:17]=[CH:18][C:19]([C:20](O)=[O:21])=[C:15]3[N:14]=[CH:13][C:12]=2[C:23]([N:25]2[CH2:30][CH2:29][CH:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH2:27][CH2:26]2)=[O:24])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[CH3:37][S:38]([NH2:41])(=[O:40])=[O:39]>>[CH:1]1([NH:10][C:11]2[N:16]3[N:17]=[CH:18][C:19]([C:20]([NH:41][S:38]([CH3:37])(=[O:40])=[O:39])=[O:21])=[C:15]3[N:14]=[CH:13][C:12]=2[C:23]([N:25]2[CH2:30][CH2:29][CH:28]([C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)[CH2:27][CH2:26]2)=[O:24])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 72879Methanesulfonamide

HCID 67540841HCID 67540841, compound

Product 1

HCID 67540773HCID 67540773, compoundYield 57%

Procedure

In the same manner as in Example 1, step 6 and using 7-(2,3-dihydro-1H-inden-1-ylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (50 mg, 0.104 mmol) obtained in step 2 and methanesulfonamide (39 mg, 0.42 mmol), the title compound (33 mg, 57%) was obtained.

Sources & evidence

ORD record: ord-7a014e73430b4195982e69a8c8dcc9d1
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

Loading…