Methanesulfonamide → HCID 67540387, compound

HRID 1026909Notes

Reaction equation

HRID 1026909 reaction equation
[CH2:1]([NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([C:18](O)=[O:19])=[C:13]2[N:12]=[CH:11][C:10]=1[C:21]([N:23]1[CH2:28][CH2:27][CH:26]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[O:35][CH3:36])[CH2:25][CH2:24]1)=[O:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:37][S:38]([NH2:41])(=[O:40])=[O:39]>>[CH2:1]([NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([C:18]([NH:41][S:38]([CH3:37])(=[O:40])=[O:39])=[O:19])=[C:13]2[N:12]=[CH:11][C:10]=1[C:21]([N:23]1[CH2:24][CH2:25][CH:26]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[O:35][CH3:36])[CH2:27][CH2:28]1)=[O:22])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 72879MethanesulfonamideHCID 67540606HCID 67540606, compound

Product 1

HCID 67540387HCID 67540387, compoundYield 56%

Procedure

In the same manner as in Example 1, step 6 and using 7-benzylamino-6-[4-(2-methoxyphenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.153 g, 0.317 mmol) obtained in step 5 and methanesulfonamide (0.175 g, 1.85 mmol), the title compound (0.099 g, 56%) was obtained.

Sources & evidence

ORD record
ord-950c52f792844ac8a79b14097b53c0b8
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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