HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(1H-pyrazol-1-yl)piperidine hydrochloride → 7-Benzylamino-3-bromo-6-[4-(1H-pyrazol-1-yl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(1H-pyrazol-1-yl)piperidine hydrochloride | HCID 56766486 | — |
| Reactant | 7-Benzylamino-3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylic acid | HCID 67540363 | — |
| Product | 7-Benzylamino-3-bromo-6-[4-(1H-pyrazol-1-yl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine | HCID 67540850 | 52% |
Reaction Steps
In the same manner as in Example 21, step 5 and using 7-benzylamino-3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.215 g, 0.625 mmol) obtained in Example 22, step 3 and 4-(1H-pyrazol-1-yl)piperidine hydrochloride (WO2004/094371, 0.129 g, 0.687 mmol), the title compound (0.155 g, 52%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729264B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-03884d6a27234c9eb35a373414831279 |
| Source note | uspto-grants-2014_05 |