HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Fluorophenyl)piperidine--hydrogen chloride (1/1) → 7-Benzylamino-3-bromo-6-[4-(2-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Fluorophenyl)piperidine--hydrogen chloride (1/1) | HCID 21936944 | — |
| Reactant | 7-Benzylamino-3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylic acid | HCID 67540363 | — |
| Product | 7-Benzylamino-3-bromo-6-[4-(2-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine | HCID 67540953 | 136.1% |
Reaction Steps
In the same manner as in Example 21, step 5 and using 7-benzylamino-3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.174 g, 0.506 mmol) obtained in Example 22, step 3 and 4-(2-fluorophenyl)piperidine hydrochloride (0.120 g, 0.556 mmol), the title compound (0.35 g, 90%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729264B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-eec39878a0224abfba97f591cb1336f9 |
| Source note | uspto-grants-2014_05 |