Methanesulfonamide → HCID 67539494, compound

HRID 1026925Notes

Reaction equation

HRID 1026925 reaction equation
[CH2:1]([NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([C:18]([OH:20])=O)=[C:13]2[N:12]=[CH:11][C:10]=1[C:21]([N:23]1[CH2:28][CH2:27][CH:26]([C:29]2[CH:30]=[N:31][CH:32]=[N:33][CH:34]=2)[CH2:25][CH2:24]1)=[O:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:35][S:36]([NH2:39])(=[O:38])=[O:37]>>[CH2:1]([NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([C:18]([NH:39][S:36]([CH3:35])(=[O:38])=[O:37])=[O:20])=[C:13]2[N:12]=[CH:11][C:10]=1[C:21]([N:23]1[CH2:24][CH2:25][CH:26]([C:29]2[CH:30]=[N:31][CH:32]=[N:33][CH:34]=2)[CH2:27][CH2:28]1)=[O:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 72879MethanesulfonamideHCID 67540369HCID 67540369, compound

Product 1

HCID 67539494HCID 67539494, compoundYield 26%

Procedure

In the same manner as in Example 1, step 6 and using 7-benzylamino-6-[4-(pyrimidin-5-yl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.14 g, 0.29 mmol) obtained in step 2 and methanesulfonamide (0.138 g, 1.45 mmol), the title compound (0.04 g, 26%) was obtained.

Sources & evidence

ORD record
ord-721ff34bd35748ffb9bc1667eb4d9364
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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