4-Methyl-4-phenylpiperidine → HCID 178469970, compound

HRID 1026930Notes

Reaction equation

HRID 1026930 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([OH:15])=[C:13]([C:16]([OH:18])=O)[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2].[CH3:19][C:20]1([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([OH:15])=[C:13]([C:16]([N:23]3[CH2:24][CH2:25][C:20]([CH3:19])([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[CH2:21][CH2:22]3)=[O:18])[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 30195114-Methyl-4-phenylpiperidineHCID 178469973HCID 178469973, compound

Product 1

HCID 178469970HCID 178469970, compoundYield 69%

Procedure

In the same manner as in Example 1, step 2 and using 3-ethoxycarbonyl-7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylic acid (583 mg, 2.32 mmol) obtained in Example 19, step 2 and 4-methyl-4-phenylpiperidine (Journal of Medicinal Chemistry, vol. 41, page 5320, 590 mg, 2.79 mmol), the title compound (650 mg, 69%) was obtained.

Sources & evidence

ORD record
ord-f5d443cf4e3341da919f42e2b2b7d783
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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