1-(2-Chlorophenyl)piperazine → HCID 67539977, compound

HRID 1026935Notes

Reaction equation

HRID 1026935 reaction equation
[CH2:1]([NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([Br:18])=[C:13]2[N:12]=[CH:11][C:10]=1[C:19]([OH:21])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[CH2:1]([NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([Br:18])=[C:13]2[N:12]=[CH:11][C:10]=1[C:19]([N:32]1[CH2:31][CH2:30][N:29]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2[Cl:22])[CH2:34][CH2:33]1)=[O:21])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 4156281-(2-Chlorophenyl)piperazineHCID 675403637-Benzylamino-3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylic acid

Product 1

HCID 67539977HCID 67539977, compoundYield 81.2%

Procedure

In the same manner as in Example 21, step 5 and using 7-benzylamino-3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.091 g, 0.243 mmol) obtained in Example 22, step 3 and 1-(2-chlorophenyl)piperazine (0.057 g, 0.239 mmol), the title compound (0.102 g, 69%) was obtained.

Sources & evidence

ORD record
ord-51edd40fa78d4de69d725eafdb20330a
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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