Acetonitrile → HCID 67541052, compound

Participants

Reaction Conditions

Reaction Steps

N-[7-(2-Methylthiophenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carbonyl]ethanesulfonamide (0.02 g, 0.03 mmol) obtained in Example 45, step 3 was dissolved in acetonitrile (1 mL) and water (0.5 mL), OXONE (0.05 mg, 0.08 mmol) was added, and the mixture was stirred at 40° C. for 1 hr. Aqueous sodium thiosulfate solution was added to the reaction mixture, and the mixture was extracted with chloroform. The organic layer was washed with water, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform/methanol=95/5) to give the title compound (0.02 g, 71%).

Provenance & Evidence