Cyclopropanesulfonamide → HCID 67540374, compound

HRID 1026948Notes

Reaction equation

[C:1]1([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]1[N:13]2[N:14]=[CH:15][C:16]([C:17](O)=[O:18])=[C:12]2[N:11]=[CH:10][C:9]=1[C:20]([N:22]1[CH2:27][CH2:26][CH:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:24][CH2:23]1)=[O:21].[CH:40]1([S:43]([NH2:46])(=[O:45])=[O:44])[CH2:42][CH2:41]1>>[C:1]1([C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]1[N:13]2[N:14]=[CH:15][C:16]([C:17]([NH:46][S:43]([CH:40]3[CH2:42][CH2:41]3)(=[O:45])=[O:44])=[O:18])=[C:12]2[N:11]=[CH:10][C:9]=1[C:20]([N:22]1[CH2:27][CH2:26][CH:25]([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:24][CH2:23]1)=[O:21]

Participants

Reactant 2

HCID 15765418Cyclopropanesulfonamide

HCID 67539671HCID 67539671, compound

Product 1

HCID 67540374HCID 67540374, compoundYield 27%

Procedure

In the same manner as in Example 1, step 6 and using 7-(biphenyl-2-ylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (61 mg, 0.14 mmol) obtained in step 2 and cyclopropanesulfonamide (73 mg, 0.70 mmol), the title compound (21 mg, 27%) was obtained.

Sources & evidence

ORD record: ord-078712a4103e4bd086150c0d601fbed4
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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