Ethanesulfonamide → HCID 67540800, compound

HRID 1026949Notes

Reaction equation

[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:15][C:16]1[N:21]2[N:22]=[CH:23][C:24]([C:25](O)=[O:26])=[C:20]2[N:19]=[CH:18][C:17]=1[C:28]([N:30]1[CH2:35][CH2:34][CH:33]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH2:32][CH2:31]1)=[O:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:42]([S:44]([NH2:47])(=[O:46])=[O:45])[CH3:43]>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:15][C:16]1[N:21]2[N:22]=[CH:23][C:24]([C:25]([NH:47][S:44]([CH2:42][CH3:43])(=[O:46])=[O:45])=[O:26])=[C:20]2[N:19]=[CH:18][C:17]=1[C:28]([N:30]1[CH2:35][CH2:34][CH:33]([C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH2:32][CH2:31]1)=[O:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 73702Ethanesulfonamide

HCID 67540386HCID 67540386, compound

Product 1

HCID 67540800HCID 67540800, compoundYield 63%

Procedure

In the same manner as in Example 1, step 6 and using 7-(2-benzyloxyphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (200 mg, 0.37 mmol) obtained in step 2 and ethanesulfonamide (192 mg, 1.85 mmol), the title compound (146 mg, 63%) was obtained.

Sources & evidence

ORD record: ord-ed430720e803432ca589f84840badc34
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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