Cyclopropanesulfonamide → HCID 67540806, compound

HRID 1026951Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([C:18]([OH:20])=O)=[C:13]3[N:12]=[CH:11][C:10]=2[C:21]([N:23]2[CH2:28][CH2:27][CH:26]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH2:25][CH2:24]2)=[O:22])=[CH:4][CH:3]=1.[CH:35]1([S:38]([NH2:41])(=[O:40])=[O:39])[CH2:37][CH2:36]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([C:18]([NH:41][S:38]([CH:35]4[CH2:37][CH2:36]4)(=[O:40])=[O:39])=[O:20])=[C:13]3[N:12]=[CH:11][C:10]=2[C:21]([N:23]2[CH2:24][CH2:25][CH:26]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH2:27][CH2:28]2)=[O:22])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 15765418Cyclopropanesulfonamide

HCID 67540056HCID 67540056, compound

Product 1

HCID 67540806HCID 67540806, compoundYield 44.4%

Procedure

In the same manner as in Example 1, step 6 and using 7-(4-fluorophenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (55 mg, 0.12 mmol) obtained in step 2 and cyclopropanesulfonamide (72 mg, 0.59 mmol), the title compound (30 mg, 44%) was obtained.

Sources & evidence

ORD record: ord-aeb7794544284623a2af820c81190d9c
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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