Cyclopropanesulfonamide → HCID 67540353, compound

HRID 1026962Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[NH:12][C:13]1[N:18]2[N:19]=[CH:20][C:21]([C:22](O)=[O:23])=[C:17]2[N:16]=[CH:15][C:14]=1[C:25]([N:27]1[CH2:32][CH2:31][CH:30]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH2:29][CH2:28]1)=[O:26].[CH:39]1([S:42]([NH2:45])(=[O:44])=[O:43])[CH2:41][CH2:40]1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:9])[F:10])=[CH:4][C:3]=1[NH:12][C:13]1[N:18]2[N:19]=[CH:20][C:21]([C:22]([NH:45][S:42]([CH:39]3[CH2:41][CH2:40]3)(=[O:44])=[O:43])=[O:23])=[C:17]2[N:16]=[CH:15][C:14]=1[C:25]([N:27]1[CH2:32][CH2:31][CH:30]([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH2:29][CH2:28]1)=[O:26]

Participants

Reactant 2

HCID 15765418Cyclopropanesulfonamide

HCID 67539988HCID 67539988, compound

Product 1

HCID 67540353HCID 67540353, compoundYield 45.4%

Procedure

In the same manner as in Example 1, step 6 and using 7-(2-methyl-5-trifluoromethylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (100 mg, 0.19 mmol) obtained in step 2 and cyclopropanesulfonamide (115 mg, 0.95 mmol), the title compound (54 mg, 45%) was obtained.

Sources & evidence

ORD record: ord-b7a7c735086244f886dfcd0d9db56ad5
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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