2-Chloro-5-methylaniline → HCID 67540746, compound

HRID 1026968Notes

Reaction equation

HRID 1026968 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([O:18][CH3:19])=[O:17].[Cl:20][C:21]1[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][C:22]=1[NH2:23]>>[Cl:20][C:21]1[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][C:22]=1[NH:23][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([O:18][CH3:19])=[O:17]

Participants

3

Reactant 2

HCID 667702-Chloro-5-methylanilineHCID 86646292HCID 86646292, compound

Product 1

HCID 67540746HCID 67540746, compoundYield 100.3%

Procedure

In the same manner as in Example 1, step 4 and using methyl 7-chloro-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine-6-carboxylate (2.2 g, 7.13 mmol) obtained in Example 21, step 2 and 2-chloro-5-methylaniline (1.64 g, 11.6 mmol), the title compound (2.78 g, 92%) was obtained.

Sources & evidence

ORD record
ord-a5eb7b14ba8f4f428278f7facdf7a061
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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