Ethanesulfonamide → HCID 67540831, compound

HRID 1026972Notes

Reaction equation

[CH2:1]1[C:9]2[C:4](=[C:5]([NH:10][C:11]3[N:16]4[N:17]=[CH:18][C:19]([C:20](O)=[O:21])=[C:15]4[N:14]=[CH:13][C:12]=3[C:23]([N:25]3[CH2:30][CH2:29][CH:28]([C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)[CH2:27][CH2:26]3)=[O:24])[CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[CH2:37]([S:39]([NH2:42])(=[O:41])=[O:40])[CH3:38]>>[CH2:1]1[C:9]2[C:4](=[C:5]([NH:10][C:11]3[N:16]4[N:17]=[CH:18][C:19]([C:20]([NH:42][S:39]([CH2:37][CH3:38])(=[O:41])=[O:40])=[O:21])=[C:15]4[N:14]=[CH:13][C:12]=3[C:23]([N:25]3[CH2:26][CH2:27][CH:28]([C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=4)[CH2:29][CH2:30]3)=[O:24])[CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 73702Ethanesulfonamide

HCID 67540142HCID 67540142, compound

Product 1

HCID 67540831HCID 67540831, compoundYield 74%

Procedure

In the same manner as in Example 1, step 6 and using 7-(2,3-dihydro-1H-inden-4-ylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (90 mg, 0.19 mmol) obtained in step 2 and ethanesulfonamide (99 mg, 0.94 mmol), the title compound (78 mg, 74%) was obtained.

Sources & evidence

ORD record: ord-449a7cb176db4c72977509fed15e82eb
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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