Ethanesulfonamide → HCID 67540370, compound

HRID 1026973Notes

Reaction equation

[CH3:1][N:2]1[C:6]([NH:7][C:8]2[N:13]3[N:14]=[CH:15][C:16]([C:17](O)=[O:18])=[C:12]3[N:11]=[CH:10][C:9]=2[C:20]([N:22]2[CH2:27][CH2:26][CH:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:24][CH2:23]2)=[O:21])=[CH:5][CH:4]=[N:3]1.[CH2:34]([S:36]([NH2:39])(=[O:38])=[O:37])[CH3:35]>>[CH3:1][N:2]1[C:6]([NH:7][C:8]2[N:13]3[N:14]=[CH:15][C:16]([C:17]([NH:39][S:36]([CH2:34][CH3:35])(=[O:38])=[O:37])=[O:18])=[C:12]3[N:11]=[CH:10][C:9]=2[C:20]([N:22]2[CH2:27][CH2:26][CH:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:24][CH2:23]2)=[O:21])=[CH:5][CH:4]=[N:3]1

Participants

Reactant 2

HCID 73702Ethanesulfonamide

HCID 67540636HCID 67540636, compound

Product 1

HCID 67540370HCID 67540370, compoundYield 30.1%

Procedure

In the same manner as in Example 1, step 6 and using 7-(1-methylpyrazol-5-yl)amino-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.074 g, 0.167 mmol) obtained in step 2 and ethanesulfonamide (0.091 g, 0.833 mmol), the title compound (0.027 g, 30%) was obtained.

Sources & evidence

ORD record: ord-e4e9a922f8554ff1bf5fdbcac54b5a66
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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