Cyclopropanesulfonamide → HCID 67540835, compound

HRID 1026977Notes

Reaction equation

[CH3:1][C:2]1[C:3]([NH:7][C:8]2[N:13]3[N:14]=[CH:15][C:16]([C:17]([OH:19])=O)=[C:12]3[N:11]=[CH:10][C:9]=2[C:20]([N:22]2[CH2:27][CH2:26][CH:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:24][CH2:23]2)=[O:21])=[CH:4][S:5][CH:6]=1.[CH:34]1([S:37]([NH2:40])(=[O:39])=[O:38])[CH2:36][CH2:35]1>>[CH3:1][C:2]1[C:3]([NH:7][C:8]2[N:13]3[N:14]=[CH:15][C:16]([C:17]([NH:40][S:37]([CH:34]4[CH2:36][CH2:35]4)(=[O:39])=[O:38])=[O:19])=[C:12]3[N:11]=[CH:10][C:9]=2[C:20]([N:22]2[CH2:27][CH2:26][CH:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:24][CH2:23]2)=[O:21])=[CH:4][S:5][CH:6]=1

Participants

Reactant 2

HCID 15765418Cyclopropanesulfonamide

HCID 67541302HCID 67541302, compound

Product 1

HCID 67540835HCID 67540835, compoundYield 8%

Procedure

In the same manner as in Example 1, step 6 and using 7-(4-methyl-3-thienylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.05 g, 0.11 mmol) obtained in step 2 and cyclopropanesulfonamide (0.048 g, 0.44 mmol), the title compound (0.005 g, 8%) was obtained.

Sources & evidence

ORD record: ord-2957f1c4fbe346ea9962c41b4cd1df09
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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