Ethanesulfonamide → HCID 67540843, compound

HRID 1026989Notes

Reaction equation

[CH3:1][N:2]1[C:10]2[C:5](=[C:6]([NH:11][C:12]3[N:17]4[N:18]=[CH:19][C:20]([C:21](O)=[O:22])=[C:16]4[N:15]=[CH:14][C:13]=3[C:24]([N:26]3[CH2:31][CH2:30][CH:29]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[CH2:28][CH2:27]3)=[O:25])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3]1.[CH2:38]([S:40]([NH2:43])(=[O:42])=[O:41])[CH3:39]>>[CH3:1][N:2]1[C:10]2[C:5](=[C:6]([NH:11][C:12]3[N:17]4[N:18]=[CH:19][C:20]([C:21]([NH:43][S:40]([CH2:38][CH3:39])(=[O:42])=[O:41])=[O:22])=[C:16]4[N:15]=[CH:14][C:13]=3[C:24]([N:26]3[CH2:27][CH2:28][CH:29]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[CH2:30][CH2:31]3)=[O:25])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3]1

Participants

Reactant 2

HCID 73702Ethanesulfonamide

HCID 67539461HCID 67539461, compound

Product 1

HCID 67540843HCID 67540843, compoundYield 44.4%

Procedure

In the same manner as in Example 1, step 6 and using 7-(1-methyl-4-indolylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.05 g, 0.10 mmol) obtained in step 2 and ethanesulfonamide (0.065 g, 0.6 mmol), the title compound (0.026 g, 44%) was obtained.

Sources & evidence

ORD record: ord-776a80e1ee934e6384461a260229ee91
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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