2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-amine → HCID 67540433, compound

HRID 1026994Notes

Reaction equation

HRID 1026994 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([N:18]1[CH2:23][CH2:22][CH:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:20][CH2:19]1)=[O:17].[CH3:30][C:31]1([CH3:41])[CH2:35][C:34]2[CH:36]=[CH:37][CH:38]=[C:39]([NH2:40])[C:33]=2[O:32]1>>[CH2:14]([O:13][C:11]([C:10]1[CH:9]=[N:8][N:7]2[C:2]([NH:40][C:39]3[C:33]4[O:32][C:31]([CH3:41])([CH3:30])[CH2:35][C:34]=4[CH:36]=[CH:37][CH:38]=3)=[C:3]([C:16]([N:18]3[CH2:23][CH2:22][CH:21]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH2:20][CH2:19]3)=[O:17])[CH:4]=[N:5][C:6]=12)=[O:12])[CH3:15]

Participants

3

Reactant 2

HCID 916972,2-Dimethyl-2,3-dihydro-1-benzofuran-7-amineHCID 866462907-Chloro-3-ethoxycarbonyl-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine

Product 1

HCID 67540433HCID 67540433, compoundYield 99.9%

Procedure

In the same manner as in Example 19, step 5 and using 7-chloro-3-ethoxycarbonyl-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine (0.15 g, 0.36 mmol) obtained in Example 19, step 4 and 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-amine (0.088 g, 0.54 mmol), the title compound (0.194 g, 99%) was obtained.

Sources & evidence

ORD record
ord-1c9a1a853c6a4e338ff2f9131ee6ca2d
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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