Ethanesulfonamide → HCID 67541093, compound

HRID 1026995Notes

Reaction equation

[CH3:1][C:2]1([CH3:38])[CH2:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([NH:11][C:12]3[N:17]4[N:18]=[CH:19][C:20]([C:21](O)=[O:22])=[C:16]4[N:15]=[CH:14][C:13]=3[C:24]([N:26]3[CH2:31][CH2:30][CH:29]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[CH2:28][CH2:27]3)=[O:25])[C:4]=2[O:3]1.[CH2:39]([S:41]([NH2:44])(=[O:43])=[O:42])[CH3:40]>>[CH3:38][C:2]1([CH3:1])[CH2:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([NH:11][C:12]3[N:17]4[N:18]=[CH:19][C:20]([C:21]([NH:44][S:41]([CH2:39][CH3:40])(=[O:43])=[O:42])=[O:22])=[C:16]4[N:15]=[CH:14][C:13]=3[C:24]([N:26]3[CH2:31][CH2:30][CH:29]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[CH2:28][CH2:27]3)=[O:25])[C:4]=2[O:3]1

Participants

Reactant 2

HCID 73702Ethanesulfonamide

HCID 67540405HCID 67540405, compound

Product 1

HCID 67541093HCID 67541093, compoundYield 44.8%

Procedure

In the same manner as in Example 1, step 6 and using 7-(2,2-dimethyl-2,3-dihydrobenzofuran-7-ylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.05 g, 0.10 mmol) obtained in step 2 and ethanesulfonamide (0.063 g, 0.58 mmol), the title compound (0.027 g, 44%) was obtained.

Sources & evidence

ORD record: ord-efd3516bff56413ca498a2f08f49070d
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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