4-(4-Fluorophenyl)piperidine → HCID 178469969, compound

HRID 1026996Notes

Reaction equation

HRID 1026996 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([OH:15])=[C:13]([C:16]([OH:18])=O)[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2].[F:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[CH:22][CH:21]=1>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([OH:15])=[C:13]([C:16]([N:29]3[CH2:30][CH2:31][CH:26]([C:23]4[CH:22]=[CH:21][C:20]([F:19])=[CH:25][CH:24]=4)[CH2:27][CH2:28]3)=[O:18])[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 27591364-(4-Fluorophenyl)piperidineHCID 178469973HCID 178469973, compound

Product 1

HCID 178469969HCID 178469969, compoundYield 62%

Procedure

In the same manner as in Example 1, step 2 and using 3-ethoxycarbonyl-7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylic acid (1.17 g, 4.65 mmol) obtained in Example 19, step 2 and 4-(4-fluorophenyl)piperidine (1.0 g, 5.58 mmol), the title compound (1.18 g, 62%) was obtained.

Sources & evidence

ORD record
ord-25eb6fb8857c4c7dbe2694045de1b91e
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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