2,5-Dimethylaniline → HCID 67540299, compound

HRID 1027006Notes

Reaction equation

HRID 1027006 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([N:18]1[CH2:23][CH2:22][CH:21]([C:24]2[CH:29]=[CH:28][C:27](F)=[CH:26][CH:25]=2)[CH2:20][CH2:19]1)=[O:17].[CH3:31][C:32]1[CH:38]=[CH:37][C:36]([CH3:39])=[CH:35][C:33]=1[NH2:34]>>[CH3:31][C:32]1[CH:38]=[CH:37][C:36]([CH3:39])=[CH:35][C:33]=1[NH:34][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([N:18]1[CH2:23][CH2:22][CH:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:20][CH2:19]1)=[O:17]

Participants

3

Reactant 2

HCID 72592,5-DimethylanilineHCID 86646293HCID 86646293, compound

Product 1

HCID 67540299HCID 67540299, compoundYield 103.1%

Procedure

In the same manner as in Example 19, step 5 and using 7-chloro-3-ethoxycarbonyl-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine (0.10 g, 0.23 mmol) obtained in Example 81, step 2 and 2,5-dimethylaniline (0.042 g, 0.35 mmol), the title compound (0.118 g, 99%) was obtained.

Sources & evidence

ORD record
ord-8deb2cdd460440d58ac15439e3538aa8
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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