2,5-Dimethylaniline → HCID 67541229, compound

HRID 1027009Notes

Reaction equation

HRID 1027009 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([O:18][CH3:19])=[O:17].[CH3:20][C:21]1[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][C:22]=1[NH2:23]>>[CH3:20][C:21]1[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][C:22]=1[NH:23][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([O:18][CH3:19])=[O:17]

Participants

3

Reactant 2

HCID 72592,5-DimethylanilineHCID 86646292HCID 86646292, compound

Product 1

HCID 67541229HCID 67541229, compoundYield 82%

Procedure

In the same manner as in Example 1, step 4 and using methyl 7-chloro-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine-6-carboxylate (2.8 g, 9.9 mmol) obtained in Example 21, step 2 and 2,5-dimethylaniline (1.5 mL, 11.8 mmol), the title compound (2.99 g, 81%) was obtained.

Sources & evidence

ORD record
ord-045764299e33459bbdd345268ac6e292
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

Loading…