2-Fluoro-5-methylaniline → HCID 67540775, compound

HRID 1027013Notes

Reaction equation

HRID 1027013 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([O:18][CH3:19])=[O:17].[F:20][C:21]1[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][C:22]=1[NH2:23]>>[CH2:14]([O:13][C:11]([C:10]1[CH:9]=[N:8][N:7]2[C:2]([NH:23][C:22]3[CH:24]=[C:25]([CH3:28])[CH:26]=[CH:27][C:21]=3[F:20])=[C:3]([C:16]([O:18][CH3:19])=[O:17])[CH:4]=[N:5][C:6]=12)=[O:12])[CH3:15]

Participants

3

Reactant 2

HCID 2629702-Fluoro-5-methylanilineHCID 86646292HCID 86646292, compound

Product 1

HCID 67540775HCID 67540775, compoundYield 47%

Procedure

In the same manner as in Example 1, step 4 and using methyl 7-chloro-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine-6-carboxylate (4.0 g, 14.0 mmol) obtained in Example 21, step 2 and 2-fluoro-5-methylaniline (2.4 mL, 20.9 mmol), the title compound (2.45 g, 47%) was obtained.

Sources & evidence

ORD record
ord-4efbc0d1289e4bc295ba2f3debfe7d8e
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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