HRID1027017

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22252853

4-(4-Methoxyphenyl)piperidine--hydrogen chloride (1/1)

C12H18ClNO

结构：CCOC(=O)c1cnn2c(Nc3cc(C)ccc3F)c(C(=O)O)cnc12

HCID67540774

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cnn2c(Nc3cc(C)ccc3F)c(C(=O)N3CCC(c4ccc(OC)cc4)CC3)cnc12

HCID67539990

未命名化合物

收率 78%

PROCEDURE

实验过程

In the same manner as in Example 21, step 5 and using 3-ethoxycarbonyl-7-(2-fluoro-5-methylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.5 g, 1.40 mmol) obtained in Example 90, step 2 and 4-(4-methoxyphenyl)piperidine hydrochloride (0.38 mg, 1.67 mmol), the title compound (0.58 mg, 78%) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f4ff623002f64eb6b5459a310b010ab7
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08729264B2
来源说明: uspto-grants-2014_05

反应 SMILES

[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([NH:15][C:16]3[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:17]=3[F:23])=[C:13]([C:24]([OH:26])=O)[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2].Cl.[CH3:28][O:29][C:30]1[CH:35]=[CH:34][C:33]([CH:36]2[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]2)=[CH:32][CH:31]=1>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([NH:15][C:16]3[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:17]=3[F:23])=[C:13]([C:24]([N:39]3[CH2:40][CH2:41][CH:36]([C:33]4[CH:32]=[CH:31][C:30]([O:29][CH3:28])=[CH:35][CH:34]=4)[CH2:37][CH2:38]3)=[O:26])[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2]