Ethanesulfonamide → HCID 67541410, compound

HRID 1027023Notes

Reaction equation

[CH:1]1([CH:7]2[CH2:12][CH2:11][N:10]([C:13]([C:15]3[CH:16]=[N:17][C:18]4[N:19]([N:30]=[CH:31][C:32]=4[C:33](O)=[O:34])[C:20]=3[NH:21][C:22]3[CH:27]=[C:26]([CH3:28])[CH:25]=[CH:24][C:23]=3[CH3:29])=[O:14])[CH2:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:36]([S:38]([NH2:41])(=[O:40])=[O:39])[CH3:37]>>[CH:1]1([CH:7]2[CH2:8][CH2:9][N:10]([C:13]([C:15]3[CH:16]=[N:17][C:18]4[N:19]([N:30]=[CH:31][C:32]=4[C:33]([NH:41][S:38]([CH2:36][CH3:37])(=[O:40])=[O:39])=[O:34])[C:20]=3[NH:21][C:22]3[CH:27]=[C:26]([CH3:28])[CH:25]=[CH:24][C:23]=3[CH3:29])=[O:14])[CH2:11][CH2:12]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

Reactant 2

HCID 73702Ethanesulfonamide

HCID 67540687HCID 67540687, compound

Product 1

HCID 67541410HCID 67541410, compoundYield 55.1%

Procedure

In the same manner as in Example 1, step 6 and using 6-(4-cyclohexylpiperidine-1-carbonyl)-7-(2,5-dimethylphenylamino)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (75 mg, 0.16 mmol) obtained in step 2 and ethanesulfonamide (84 mg, 0.80 mmol), the title compound (50 mg, 55%) was obtained.

Sources & evidence

ORD record: ord-6783bdbed3e0446a835828cfde22f779
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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