HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-4-phenylpiperidine → 7-Benzylamino-3-bromo-6-(4-fluoro-4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-4-phenylpiperidine | HCID 45933760 | — |
| Reactant | 7-Benzylamino-3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylic acid | HCID 67540363 | — |
| Product | 7-Benzylamino-3-bromo-6-(4-fluoro-4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine | HCID 67540485 | 86.1% |
Reaction Steps
In the same manner as in Example 21, step 5 and using 7-benzylamino-3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.500 g, 1.44 mmol) obtained in Example 22, step 3 and 4-fluoro-4-phenylpiperidine (WO2002/13824, 0.340 g, 1.73 mmol), the title compound (0.630 g, 86%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729264B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-4f9be240cdf24ef381419c9be4a80bdf |
| Source note | uspto-grants-2014_05 |