Methanesulfonamide → HCID 67541412, compound

HRID 1027025Notes

Reaction equation

HRID 1027025 reaction equation
[CH2:1]([NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([C:18]([OH:20])=O)=[C:13]2[N:12]=[CH:11][C:10]=1[C:21]([N:23]1[CH2:28][CH2:27][C:26]([F:35])([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:25][CH2:24]1)=[O:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:36][S:37]([NH2:40])(=[O:39])=[O:38]>>[CH2:1]([NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([C:18]([NH:40][S:37]([CH3:36])(=[O:39])=[O:38])=[O:20])=[C:13]2[N:12]=[CH:11][C:10]=1[C:21]([N:23]1[CH2:24][CH2:25][C:26]([F:35])([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:27][CH2:28]1)=[O:22])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 72879MethanesulfonamideHCID 67541160HCID 67541160, compound

Product 1

HCID 67541412HCID 67541412, compoundYield 75.3%

Procedure

In the same manner as in Example 1, step 6 and using 7-benzylamino-6-(4-fluoro-4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.030 g, 0.634 mmol) obtained in step 2 and methanesulfonamide (0.064 g, 0.676 mmol), the title compound (0.263 g, 75%) was obtained.

Sources & evidence

ORD record
ord-1b23cd6185db425bbaa9a87a21716c7f
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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