4-Fluoro-4-phenylpiperidine hydrochloride → HCID 178469971, compound

HRID 1027026Notes

Reaction equation

HRID 1027026 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([OH:15])=[C:13]([C:16]([OH:18])=O)[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2].Cl.[F:20][C:21]1([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([OH:15])=[C:13]([C:16]([N:24]3[CH2:25][CH2:26][C:21]([F:20])([C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH2:22][CH2:23]3)=[O:18])[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 459337594-Fluoro-4-phenylpiperidine hydrochlorideHCID 178469973HCID 178469973, compound

Product 1

HCID 178469971HCID 178469971, compoundYield 68%

Procedure

In the same manner as in Example 1, step 2 and using 3-ethoxycarbonyl-7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylic acid (1.55 g, 6.18 mmol) obtained in Example 19, step 2 and 4-fluoro-4-phenylpiperidine hydrochloride (2.0 g, 9.27 mmol), the title compound (1.72 g, 68%) was obtained.

Sources & evidence

ORD record
ord-57914d262fbb457b884d27c7739daa24
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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