4-Fluoro-2-methylaniline → HCID 67540782, compound

HRID 1027027Notes

Reaction equation

HRID 1027027 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([N:18]1[CH2:23][CH2:22][C:21]([F:30])([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:20][CH2:19]1)=[O:17].[F:31][C:32]1[CH:38]=[CH:37][C:35]([NH2:36])=[C:34]([CH3:39])[CH:33]=1>>[CH2:14]([O:13][C:11]([C:10]1[CH:9]=[N:8][N:7]2[C:2]([NH:36][C:35]3[CH:37]=[CH:38][C:32]([F:31])=[CH:33][C:34]=3[CH3:39])=[C:3]([C:16]([N:18]3[CH2:19][CH2:20][C:21]([F:30])([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH2:22][CH2:23]3)=[O:17])[CH:4]=[N:5][C:6]=12)=[O:12])[CH3:15]

Participants

3

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 86646294HCID 86646294, compound

Product 1

HCID 67540782HCID 67540782, compoundYield 73%

Procedure

In the same manner as in Example 19, step 5 and using 7-chloro-3-ethoxycarbonyl-6-(4-fluoro-4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine (250 mg, 0.58 mmol) obtained in step 2 and 4-fluoro-2-methylaniline (0.1 mL, 0.87 mmol), the title compound (219 mg, 73%) was obtained.

Sources & evidence

ORD record
ord-5095b175b31046eebf309151ac4c1aae
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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