2-Fluoro-5-methylaniline → HCID 67541309, compound

HRID 1027030Notes

Reaction equation

HRID 1027030 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][N:5]2[C:10](Cl)=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:8]=[N:7][C:6]=12.[F:17][C:18]1[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][C:19]=1[NH2:20]>>[Br:1][C:2]1[CH:3]=[N:4][N:5]2[C:10]([NH:20][C:19]3[CH:21]=[C:22]([CH3:25])[CH:23]=[CH:24][C:18]=3[F:17])=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:8]=[N:7][C:6]=12

Participants

3

Reactant 2

HCID 2629702-Fluoro-5-methylanilineHCID 57345881Ethyl 3-bromo-7-chloropyrazolo[1,5-a]pyrimidine-6-carboxylate

Product 1

HCID 67541309HCID 67541309, compoundYield 91%

Procedure

In the same manner as in Example 1, step 4 and using ethyl 3-bromo-7-chloropyrazolo[1,5-a]pyrimidine-6-carboxylate (400 mg, 1.31 mmol) obtained in Example 22, step 1 and 2-fluoro-5-methylaniline (0.18 mL, 1.57 mmol), the title compound (410 mg, 91%) was obtained.

Sources & evidence

ORD record
ord-4d3dffcf55524c5eb87fa198b6dc8ed8
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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