HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-4-phenylpiperidine hydrochloride → 3-Bromo-7-(2,5-dimethylphenylamino)-6-(4-fluoro-4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-4-phenylpiperidine hydrochloride | HCID 45933759 | — |
| Reactant | 3-Bromo-7-(2,5-dimethylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid | HCID 67539968 | — |
| Product | 3-Bromo-7-(2,5-dimethylphenylamino)-6-(4-fluoro-4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine | HCID 67540890 | 62.2% |
Reaction Steps
In the same manner as in Example 21, step 5 and using 3-bromo-7-(2,5-dimethylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid (231 mg, 0.64 mmol) obtained in step 2 and 4-fluoro-4-phenylpiperidine hydrochloride (207 mg, 0.96 mmol), the title compound (208 mg, 62%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729264B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-5259068c04c04d1ea675cdeec8da906c |
| Source note | uspto-grants-2014_05 |