HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid → 3-Bromo-6-[4-fluoro-4-(4-fluorophenyl)piperidine-1-carbonyl]-7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid | HCID 67540052 | — |
| Reactant | 4-Fluoro-4-(4-fluorophenyl)piperidine hydrochloride | HCID 67540826 | — |
| Product | 3-Bromo-6-[4-fluoro-4-(4-fluorophenyl)piperidine-1-carbonyl]-7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine | HCID 67540632 | 48.3% |
Reaction Steps
In the same manner as in Example 21, step 5 and using 3-bromo-7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid (100 mg, 0.27 mmol) obtained in step 2 and 4-fluoro-4-(4-fluorophenyl)piperidine hydrochloride (WO2008/012622, 71 mg, 0.33 mmol), the title compound (71 mg, 48%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729264B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-490e8e22aa7a4e628207b799a85b0c41 |
| Source note | uspto-grants-2014_05 |