Ethanesulfonamide → HCID 67541258, compound

HRID 1027040Notes

Reaction equation

HRID 1027040 reaction equation
[F:1][C:2]1([C:31]2[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=2)[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:11]=[N:12][C:13]3[N:14]([N:25]=[CH:26][C:27]=3[C:28](O)=[O:29])[C:15]=2[NH:16][C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=2[CH3:24])=[O:9])[CH2:4][CH2:3]1.[CH2:38]([S:40]([NH2:43])(=[O:42])=[O:41])[CH3:39]>>[F:1][C:2]1([C:31]2[CH:32]=[CH:33][C:34]([F:37])=[CH:35][CH:36]=2)[CH2:3][CH2:4][N:5]([C:8]([C:10]2[CH:11]=[N:12][C:13]3[N:14]([N:25]=[CH:26][C:27]=3[C:28]([NH:43][S:40]([CH2:38][CH3:39])(=[O:42])=[O:41])=[O:29])[C:15]=2[NH:16][C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=2[CH3:24])=[O:9])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 73702EthanesulfonamideHCID 67540352HCID 67540352, compound

Product 1

HCID 67541258HCID 67541258, compoundYield 30%

Procedure

In the same manner as in Example 1, step 6 and using 6-[4-fluoro-4-(4-fluorophenyl)piperidine-1-carbonyl]-7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (26 mg, 0.05 mmol) obtained in step 4 and ethanesulfonamide (27 mg, 0.26 mmol), the title compound (9 mg, 30%) was obtained.

Sources & evidence

ORD record
ord-8ce53d42eda641a3a345018a10b990d3
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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