HRID1027041

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)c1cnn2c(Nc3cc(C)ccc3C)c(C(=O)O)cnc12

HCID67540739

未命名化合物

HCID67540826

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cnn2c(Nc3cc(C)ccc3C)c(C(=O)N3CCC(F)(c4ccc(F)cc4)CC3)cnc12

HCID67540692

未命名化合物

收率 54%

PROCEDURE

实验过程

In the same manner as in Example 21, step 5 and using 7-(2,5-dimethylphenylamino)-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (100 mg, 0.28 mmol) obtained in Example 88, step 2 and 4-fluoro-4-(4-fluorophenyl)piperidine hydrochloride (79 mg, 0.34 mmol), the title compound (80 mg, 54%) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f111c9bbd9794fbea84e36531a82143c
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08729264B2
来源说明: uspto-grants-2014_05

反应 SMILES

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[NH:9][C:10]1[N:15]2[N:16]=[CH:17][C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:14]2[N:13]=[CH:12][C:11]=1[C:24]([OH:26])=O.Cl.[F:28][C:29]1([C:35]2[CH:40]=[CH:39][C:38]([F:41])=[CH:37][CH:36]=2)[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[NH:9][C:10]1[N:15]2[N:16]=[CH:17][C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:14]2[N:13]=[CH:12][C:11]=1[C:24]([N:32]1[CH2:31][CH2:30][C:29]([F:28])([C:35]2[CH:40]=[CH:39][C:38]([F:41])=[CH:37][CH:36]=2)[CH2:34][CH2:33]1)=[O:26]