Ethanesulfonamide → HCID 67541097, compound

HRID 1027042Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[NH:9][C:10]1[N:15]2[N:16]=[CH:17][C:18]([C:19](O)=[O:20])=[C:14]2[N:13]=[CH:12][C:11]=1[C:22]([N:24]1[CH2:29][CH2:28][C:27]([F:37])([C:30]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=2)[CH2:26][CH2:25]1)=[O:23].[CH2:38]([S:40]([NH2:43])(=[O:42])=[O:41])[CH3:39]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[NH:9][C:10]1[N:15]2[N:16]=[CH:17][C:18]([C:19]([NH:43][S:40]([CH2:38][CH3:39])(=[O:42])=[O:41])=[O:20])=[C:14]2[N:13]=[CH:12][C:11]=1[C:22]([N:24]1[CH2:29][CH2:28][C:27]([F:37])([C:30]2[CH:31]=[CH:32][C:33]([F:36])=[CH:34][CH:35]=2)[CH2:26][CH2:25]1)=[O:23]

Participants

Reactant 2

HCID 73702Ethanesulfonamide

HCID 67540169HCID 67540169, compound

Product 1

HCID 67541097HCID 67541097, compoundYield 25.1%

Procedure

In the same manner as in Example 1, step 6 and using 7-(2,5-dimethylphenylamino)-6-[4-fluoro-4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo [1,5-a]pyrimidine-3-carboxylic acid (64 mg, 0.12 mmol) obtained in step 2 and ethanesulfonamide (51 mg, 0.48 mmol), the title compound (18 mg, 25%) was obtained.

Sources & evidence

ORD record: ord-ec9ff26852564ddb93379df902648917
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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