HuagongsheHuagongshe Chemistry Print Report · For research reference only
Spiro[indene-1,4'-piperidine] hydrochloride → 7-Benzylamino-3-bromo-6-(spiro[inden-1,4'-piperidine]-1'-ylcarbonyl)pyrazolo[1,5-a]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Spiro[indene-1,4'-piperidine] hydrochloride | HCID 22509344 | — |
| Reactant | 7-Benzylamino-3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylic acid | HCID 67540363 | — |
| Product | 7-Benzylamino-3-bromo-6-(spiro[inden-1,4'-piperidine]-1'-ylcarbonyl)pyrazolo[1,5-a]pyrimidine | HCID 67541298 | 102% |
Reaction Steps
In the same manner as in Example 22, step 4 and using 7-benzylamino-3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.091 g, 0.242 mmol) obtained in Example 22, step 3 and spiro[inden-1,4′-piperidine]hydrochloride (WO2004/028459, 0.059 g, 0.267 mmol), the title compound (0.127 g, 95%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729264B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-7280e16eb9f147089611667e63005b72 |
| Source note | uspto-grants-2014_05 |