Spiro[indene-1,4'-piperidine] hydrochloride → HCID 178469967, compound

HRID 1027049Notes

Reaction equation

HRID 1027049 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([OH:15])=[C:13]([C:16]([OH:18])=O)[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2].Cl.[NH:20]1[CH2:25][CH2:24][C:23]2([C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH:27]=[CH:26]2)[CH2:22][CH2:21]1>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([OH:15])=[C:13]([C:16]([N:20]3[CH2:25][CH2:24][C:23]4([C:33]5[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=5)[CH:27]=[CH:26]4)[CH2:22][CH2:21]3)=[O:18])[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 22509344Spiro[indene-1,4'-piperidine] hydrochlorideHCID 178469973HCID 178469973, compound

Product 1

HCID 178469967HCID 178469967, compoundYield 43%

Procedure

In the same manner as in Example 1, step 2 and using 3-ethoxycarbonyl-7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.420 g, 1.68 mmol) obtained in Example 19, step 2 and spiro[inden-1,4′-piperidine]hydrochloride (0.450 g, 2.02 mmol), the title compound (0.300 g, 43%) was obtained.

Sources & evidence

ORD record
ord-686377131f2844d0af805247a94d0504
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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