4-Fluoro-2-methylaniline → HCID 67541244, compound

HRID 1027051Notes

Reaction equation

HRID 1027051 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([N:18]1[CH2:23][CH2:22][C:21]2([C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH:25]=[CH:24]2)[CH2:20][CH2:19]1)=[O:17].[F:32][C:33]1[CH:39]=[CH:38][C:36]([NH2:37])=[C:35]([CH3:40])[CH:34]=1>>[CH2:14]([O:13][C:11]([C:10]1[CH:9]=[N:8][N:7]2[C:2]([NH:37][C:36]3[CH:38]=[CH:39][C:33]([F:32])=[CH:34][C:35]=3[CH3:40])=[C:3]([C:16]([N:18]3[CH2:19][CH2:20][C:21]4([C:31]5[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=5)[CH:25]=[CH:24]4)[CH2:22][CH2:23]3)=[O:17])[CH:4]=[N:5][C:6]=12)=[O:12])[CH3:15]

Participants

3

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 86646295HCID 86646295, compound

Product 1

HCID 67541244HCID 67541244, compoundYield 88%

Procedure

In the same manner as in Example 19, step 5 and using 7-chloro-3-ethoxycarbonyl-6-(spiro[inden-1,4′-piperidine]-1′-ylcarbonyl)pyrazolo[1,5-a]pyrimidine (0.07 g, 0.16 mmol) obtained in Example 108, step 2 and 4-fluoro-2-methylaniline (0.03 g, 0.24 mmol), the title compound (0.073 g, 88%) was obtained.

Sources & evidence

ORD record
ord-5d613b0698d0494485f3d815c0526e0c
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

Loading…