Aniline → HCID 67539885, compound

HRID 1027059Notes

Reaction equation

HRID 1027059 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([N:18]1[CH2:23][CH2:22][C:21]2([C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH:25]=[C:24]2[CH3:32])[CH2:20][CH2:19]1)=[O:17].[NH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[CH2:14]([O:13][C:11]([C:10]1[CH:9]=[N:8][N:7]2[C:2]([NH:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)=[C:3]([C:16]([N:18]3[CH2:19][CH2:20][C:21]4([C:31]5[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=5)[CH:25]=[C:24]4[CH3:32])[CH2:22][CH2:23]3)=[O:17])[CH:4]=[N:5][C:6]=12)=[O:12])[CH3:15]

Participants

3

Reactant 2

HCID 6115AnilineHCID 86646296HCID 86646296, compound

Product 1

HCID 67539885HCID 67539885, compoundYield 79%

Procedure

In the same manner as in Example 19, step 5 and using 7-chloro-3-ethoxycarbonyl-6-(2-methylspiro[inden-1,4′-piperidine]-1′-ylcarbonyl)pyrazolo[1,5-a]pyrimidine (0.220 g, 0.488 mmol) obtained in step 2 and aniline (0.054 mL, 0.585 mmol), the title compound (0.191 g, 79%) was obtained.

Sources & evidence

ORD record
ord-faee702ee30f4e9baae564f81053d7b8
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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