Methanesulfonamide → HCID 67541033, compound

HRID 1027060Notes

Reaction equation

[CH3:1][C:2]1[C:10]2([CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:19]=[N:20][C:21]4[N:22]([N:31]=[CH:32][C:33]=4[C:34]([OH:36])=O)[C:23]=3[NH:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[O:17])[CH2:12][CH2:11]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1.[CH3:37][S:38]([NH2:41])(=[O:40])=[O:39]>>[CH3:1][C:2]1[C:10]2([CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:19]=[N:20][C:21]4[N:22]([N:31]=[CH:32][C:33]=4[C:34]([NH:41][S:38]([CH3:37])(=[O:40])=[O:39])=[O:36])[C:23]=3[NH:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[O:17])[CH2:12][CH2:11]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1

Participants

Reactant 2

HCID 72879Methanesulfonamide

HCID 67540482HCID 67540482, compound

Product 1

HCID 67541033HCID 67541033, compoundYield 74.1%

Procedure

In the same manner as in Example 1, step 6 and using 6-(2-methylspiro[inden-1,4′-piperidine]-1′-ylcarbonyl)-7-phenylaminopyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.030 g, 0.063 mmol) obtained in step 4 and methanesulfonamide (0.030 g, 0.313 mmol), the title compound (0.026 g, 60%) was obtained.

Sources & evidence

ORD record: ord-a582c079d21e4521ab6d9f5fbd227c89
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

Loading…