Ethanesulfonamide → HCID 67540054, compound

HRID 1027061Notes

Reaction equation

[CH3:1][C:2]1[C:10]2([CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:19]=[N:20][C:21]4[N:22]([N:31]=[CH:32][C:33]=4[C:34](O)=[O:35])[C:23]=3[NH:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[O:17])[CH2:12][CH2:11]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1.[CH2:37]([S:39]([NH2:42])(=[O:41])=[O:40])[CH3:38]>>[CH3:1][C:2]1[C:10]2([CH2:11][CH2:12][N:13]([C:16]([C:18]3[CH:19]=[N:20][C:21]4[N:22]([N:31]=[CH:32][C:33]=4[C:34]([NH:42][S:39]([CH2:37][CH3:38])(=[O:41])=[O:40])=[O:35])[C:23]=3[NH:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[O:17])[CH2:14][CH2:15]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1

Participants

Reactant 2

HCID 73702Ethanesulfonamide

HCID 67540482HCID 67540482, compound

Product 1

HCID 67540054HCID 67540054, compoundYield 63.4%

Procedure

In the same manner as in Example 1, step 6 and using 6-(2-methylspiro[inden-1,4′-piperidine]-1′-ylcarbonyl)-7-phenylaminopyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.090 g, 0.188 mmol) obtained in Example 114, step 4 and ethanesulfonamide (0.102 g, 0.939 mmol), the title compound (0.068 g, 63%) was obtained.

Sources & evidence

ORD record: ord-965eb143a6ff4c8993b06dd19eddcd39
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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