Methanesulfonamide → HCID 67541056, compound

HRID 1027062Notes

Reaction equation

HRID 1027062 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([C:18]([OH:20])=O)=[C:13]3[N:12]=[CH:11][C:10]=2[C:21]([N:23]2[CH2:28][CH2:27][C:26]3([C:36]4[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=4)[CH:30]=[C:29]3[CH3:37])[CH2:25][CH2:24]2)=[O:22])=[CH:4][CH:3]=1.[CH3:38][S:39]([NH2:42])(=[O:41])=[O:40]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([C:18]([NH:42][S:39]([CH3:38])(=[O:41])=[O:40])=[O:20])=[C:13]3[N:12]=[CH:11][C:10]=2[C:21]([N:23]2[CH2:28][CH2:27][C:26]3([C:36]4[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=4)[CH:30]=[C:29]3[CH3:37])[CH2:25][CH2:24]2)=[O:22])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 72879MethanesulfonamideHCID 67540277HCID 67540277, compound

Product 1

HCID 67541056HCID 67541056, compoundYield 71.3%

Procedure

In the same manner as in Example 1, step 6 and using 7-(4-fluorophenylamino)-6-(2-methylspiro[inden-1,4′-piperidine]-1′-ylcarbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.040 g, 0.083 mmol) obtained in step 2 and methanesulfonamide (0.040 g, 0.417 mmol), the title compound (0.034 g, 71%) was obtained.

Sources & evidence

ORD record
ord-f2f2ae8fd7b04fb4972bb47c14c5444b
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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