Methanesulfonamide → HCID 67540598, compound

HRID 1027065Notes

Reaction equation

HRID 1027065 reaction equation
[CH2:1]([NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([C:18]([OH:20])=O)=[C:13]2[N:12]=[CH:11][C:10]=1[C:21]([N:23]1[CH2:28][CH2:27][C:26]2([C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH:30]=[CH:29]2)[CH:25]([CH3:37])[CH2:24]1)=[O:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:38][S:39]([NH2:42])(=[O:41])=[O:40]>>[CH2:1]([NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([C:18]([NH:42][S:39]([CH3:38])(=[O:41])=[O:40])=[O:20])=[C:13]2[N:12]=[CH:11][C:10]=1[C:21]([N:23]1[CH2:28][CH2:27][C:26]2([C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH:30]=[CH:29]2)[CH:25]([CH3:37])[CH2:24]1)=[O:22])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 72879MethanesulfonamideHCID 67541256HCID 67541256, compound

Product 1

HCID 67540598HCID 67540598, compoundYield 79%

Procedure

In the same manner as in Example 1, step 6 and using 7-benzylamino-6-(3′-methylspiro[inden-1,4′-piperidine]-1′-ylcarbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.049 g, 0.0825 mmol) obtained in step 2 and methanesulfonamide (0.039 g, 0.413 mmol), the title compound (0.037 g, 79%) was obtained.

Sources & evidence

ORD record
ord-8362887a2cdb44929e452dcba7edac70
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

Loading…