2-Fluoro-5-methylaniline → HCID 67540575, compound

HRID 1027072Notes

Reaction equation

HRID 1027072 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([N:18]1[CH2:23][CH2:22][C:21]2([C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH2:25][CH2:24]2)[CH2:20][CH2:19]1)=[O:17].[F:32][C:33]1[CH:39]=[CH:38][C:37]([CH3:40])=[CH:36][C:34]=1[NH2:35]>>[CH2:14]([O:13][C:11]([C:10]1[CH:9]=[N:8][N:7]2[C:2]([NH:35][C:34]3[CH:36]=[C:37]([CH3:40])[CH:38]=[CH:39][C:33]=3[F:32])=[C:3]([C:16]([N:18]3[CH2:23][CH2:22][C:21]4([C:31]5[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=5)[CH2:25][CH2:24]4)[CH2:20][CH2:19]3)=[O:17])[CH:4]=[N:5][C:6]=12)=[O:12])[CH3:15]

Participants

3

Reactant 2

HCID 2629702-Fluoro-5-methylanilineHCID 86646297HCID 86646297, compound

Product 1

HCID 67540575HCID 67540575, compoundYield 90%

Procedure

In the same manner as in Example 19, step 5 and using 7-chloro-3-ethoxycarbonyl-6-(spiro[indane-1,4′-piperidine]-1′-ylcarbonyl)pyrazolo[1,5-a]pyrimidine (0.10 g, 0.23 mmol) obtained in Example 120, step 2 and 2-fluoro-5-methylaniline (0.043 g, 0.34 mmol), the title compound (0.108 g, 90%) was obtained.

Sources & evidence

ORD record
ord-dcc05b5c4290457395cb2b96bf2dd577
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

Loading…