Ethanesulfonamide → HCID 67541203, compound

HRID 1027083Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([C:18](O)=[O:19])=[C:13]2[N:12]=[CH:11][C:10]=1[C:21]([N:23]1[CH2:28][CH2:27][C:26]2([C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=3[O:30][CH2:29]2)[CH2:25][CH2:24]1)=[O:22].[CH2:37]([S:39]([NH2:42])(=[O:41])=[O:40])[CH3:38]>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([C:18]([NH:42][S:39]([CH2:37][CH3:38])(=[O:41])=[O:40])=[O:19])=[C:13]2[N:12]=[CH:11][C:10]=1[C:21]([N:23]1[CH2:28][CH2:27][C:26]2([C:36]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[O:30][CH2:29]2)[CH2:25][CH2:24]1)=[O:22]

Participants

Reactant 2

HCID 73702Ethanesulfonamide

HCID 67540912HCID 67540912, compound

Product 1

HCID 67541203HCID 67541203, compoundYield 50%

Procedure

In the same manner as in Example 1, step 6 and using 7-(2-methylphenylamino)-6-(2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.07 g, 0.14 mmol) obtained in step 2 and ethanesulfonamide (0.076 g, 0.72 mmol), the title compound (0.04 g, 50%) was obtained.

Sources & evidence

ORD record: ord-0344a8c8d1034864bcca5c6e7269bc6a
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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