HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Toluidine → 3-Ethoxycarbonyl-7-(3-methylphenylamino)-6-(2H-spiro[benzofuran-3,4'-piperidine]-1'-ylcarbonyl)pyrazolo[1,5-a]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Toluidine | HCID 7934 | — |
| Reactant | 7-Chloro-3-ethoxycarbonyl-6-(2H-spiro[benzofuran-3,4'-piperidine]-1'-ylcarbonyl)pyrazolo[1,5-a]pyrimidine | HCID 86646298 | — |
| Product | 3-Ethoxycarbonyl-7-(3-methylphenylamino)-6-(2H-spiro[benzofuran-3,4'-piperidine]-1'-ylcarbonyl)pyrazolo[1,5-a]pyrimidine | HCID 67541297 | 92% |
Reaction Steps
In the same manner as in Example 19, step 5 and using 7-chloro-3-ethoxycarbonyl-6-(2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)pyrazolo[1,5-a]pyrimidine (0.2 g, 0.45 mmol) obtained in Example 128, step 2 and m-toluidine (0.073 g, 0.68 mmol), the title compound (0.21 g, 92%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729264B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-f838e71b461547719e8501bd2fd5eda1 |
| Source note | uspto-grants-2014_05 |