Ethanesulfonamide → HCID 67541352, compound

HRID 1027085Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([C:18](O)=[O:19])=[C:13]3[N:12]=[CH:11][C:10]=2[C:21]([N:23]2[CH2:28][CH2:27][C:26]3([C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=4[O:30][CH2:29]3)[CH2:25][CH2:24]2)=[O:22])[CH:5]=[CH:6][CH:7]=1.[CH2:37]([S:39]([NH2:42])(=[O:41])=[O:40])[CH3:38]>>[CH3:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([C:18]([NH:42][S:39]([CH2:37][CH3:38])(=[O:41])=[O:40])=[O:19])=[C:13]3[N:12]=[CH:11][C:10]=2[C:21]([N:23]2[CH2:24][CH2:25][C:26]3([C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=4[O:30][CH2:29]3)[CH2:27][CH2:28]2)=[O:22])[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 73702Ethanesulfonamide

HCID 67540906HCID 67540906, compound

Product 1

HCID 67541352HCID 67541352, compoundYield 66%

Procedure

In the same manner as in Example 1, step 6 and using 7-(3-methylphenylamino)-6-(2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.75 g, 0.16 mmol) obtained in step 2 and ethanesulfonamide (0.082 g, 0.78 mmol), the title compound (0.057 g, 66%) was obtained.

Sources & evidence

ORD record: ord-97774a2f70e94761ba98d6cae55ffc1a
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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