2-Fluoro-3-methylaniline → 3-Ethoxycarbonyl-7-(2-fluoro-3-methylphenylamino)-6-(2H-spiro[benzofuran-3,4'-piperidine]-1'-ylcarbonyl)pyrazolo[1,5-a]pyrimidine

Participants

Reaction Steps

In the same manner as in Example 19, step 5 and using 7-chloro-3-ethoxycarbonyl-6-(2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)pyrazolo[1,5-a]pyrimidine (0.2 g, 0.45 mmol) obtained in Example 128, step 2 and 2-fluoro-3-methylaniline (0.085 g, 0.68 mmol), the title compound (0.2 g, 85%) was obtained.

Provenance & Evidence