Ethanesulfonamide → HCID 67541259, compound

HRID 1027092Notes

Reaction equation

HRID 1027092 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3([CH2:36][O:37][C:4]=2[CH:3]=1)[CH2:13][CH2:12][N:11]([C:14]([C:16]1[CH:17]=[N:18][C:19]2[N:20]([N:30]=[CH:31][C:32]=2[C:33](O)=[O:34])[C:21]=1[NH:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH3:29])[CH:24]=1)=[O:15])[CH2:10][CH2:9]3.[CH2:38]([S:40]([NH2:43])(=[O:42])=[O:41])[CH3:39]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3([CH2:36][O:37][C:4]=2[CH:3]=1)[CH2:13][CH2:12][N:11]([C:14]([C:16]1[CH:17]=[N:18][C:19]2[N:20]([N:30]=[CH:31][C:32]=2[C:33]([NH:43][S:40]([CH2:38][CH3:39])(=[O:42])=[O:41])=[O:34])[C:21]=1[NH:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH3:29])[CH:24]=1)=[O:15])[CH2:10][CH2:9]3

Participants

3

Reactant 2

HCID 73702EthanesulfonamideHCID 67540528HCID 67540528, compound

Product 1

HCID 67541259HCID 67541259, compoundYield 48.2%

Procedure

In the same manner as in Example 1, step 6 and using 6-(6-fluoro-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)-7-(3-methylphenylamino)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.070 g, 0.140 mmol) obtained in step 4 and ethanesulfonamide (0.076 g, 0.699 mmol), the title compound (0.040 g, 48%) was obtained.

Sources & evidence

ORD record
ord-37be47ad8ea64f0d8286f79fbcff4e08
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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